Chem 110L: Macromolecular Visualization Laboratory Exercise: Homework


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Congratulations!

You are finished with the in-class part of the tutorial. Below are two assignments that you will finish independently either at home or in the Laboratory for Computational Chemistry and Biochemistry using the program of your choice.

Homework Assignment 1

Using the program of your choice, create a movie of a rotating or rocking antibody (immunoglobulin gamma) molecule based on the crystal structure ***. Use color to distinguish the heavy and light chains. The first frame(s) of the movie should contain a textual title identifying you as a director. Your last frame(s) should contain a textual label that identifies the antigen-binding regions in the antibody. Write a brief (one paragraph) explanation about how the movie illustrates the structure and function of antibody molecules. You can upload your movie to YouTube and e-mail me the link, or leave it in your directory for grading.

Homework Assignment 2

Pick a number between 1-61. Go to http://kalev.chem.ucsb.edu/assign01/index.html. Provide your perm number and enter this number to obtain the name of a macromolecule that you will write a short non-fiction story about.

Good starting points for the material are the RCSB Molecule of the Month and the InterPro Protein of the Month web sites. You are allowed to use any other material that you find from the web, books, or scientific journals. Restrict the length of your essay to 1 page plus one illustration that you have created yourself using SYBYL, PyMOL, or any program of your choice. Please do not plagiarize, i.e. copying a paragraph directly from a web site to your paper is not allowed! You are allowed to use additional images that other people have created if you give appropriate credits but note that you should create the main illustration yourself.


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Tutorial by Dr. Kalju Kahn, Department of Chemistry and Biochemistry, UC Santa Barbara. ©2004-2011